![]() Supportive treatment includes maintaining airway, breathing, circulation and decontamination of the poison. ![]() Atropine, oximes, neuroprotection and quality care remain the mainstay of treatment for OP poisoning and can reverse the life-threatening features of acute poisoning. Early identification of the signs and symptoms and prompt management enhance better outcomes reducing mortality. This occurs as OPs irreversibly bind to acetylcholinesterase, leading to the accumulation of acetylcholine at the neuromuscular junction and subsequent over-activation of cholinergic receptors in various parts of the body. Acute poisoning by organophosphates (OPs) for suicidal purpose poses a major problem, leading to high mortality in the developing countries.
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